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MagBeads

Streptavidin Coated

Uniform magnetic bead particles for isolating and cleaning up proteins and peptides

bioZen (SPE) Sample Preparation Information


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bioZen MagBeads
Streptavidin Coated

A paramagnetic particle, ideal for isolating proteins and peptides in less time with a high response. With a unique magnetic bead particle and rigorous specifications, bioZen MagBeads are created to ensure uniform beads that provide consistent and reliable results.

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bioZen N-Glycan
Clean-Up Solid Phase Extraction

Solid phase extraction (SPE) HILIC stationary phase that excels at retention and recovery labeled released N-glycans! Microelution format allows for streamlined processing and clean-up of small sample volumes.

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Ti Biocompatible Titanium Frit
 
Traditional Stainless Steel
 
Ti Biocompatible Titanium

Pair with Phenomenex bioZen HPLC/UHPLC Columns

With a new titanium hardware to minimize priming, three particle platforms for optimal versatility and eight particle chemistries to maximize selectivity and sensitivity, bioZen UHPLC/HPLC columns are seamlessly designed to bring peace of mind to your

  • Aggregate Analysis

    Quantitation of aggregate is a critical quality attribute in biopharmaceutical development. The determination of monomer, dimer, and multimer, as well as higher order structure (quaternary structural determination of a mAb), and high/low molecular weight species are commonly observed through size exclusion chromatography.

  • Drug Antibody Ratio (DAR)

    The average drug-to-antibody ratio (DAR) is critical to assess in the development of antibody-drug conjugates (ADCs). Though different chromatography modes can be employed to determine DAR, a highly effective method utilized reversed phase chromatography.

  • Glycan Analysis

    Glycosylation of proteins-specifically monoclonal antibodies-have indications on protein structure and is arguably the most critical post-translational modification to characterize in biopharmaceutical development. N-glycan analysis through hydrophilic interaction chromatography (HILIC) is a robust method for absolute quantitation of glycoforms and is the gold standard for glycosylation characterization.

  • Intact Mass

    Intact mass analysis involves using high resolution accurate mass (HRAM) instrumentation to confirm protein sequence and identify post-translational modifications. Often in combination with reversed phase chromatography, intact mass analysis is utilized on native proteins, mAbs, and ADCs in biopharmaceutical development.

  • Intact and Fragment Analysis

    Observation of intact protein and fragmented protein during impurity profiling is essential in biologic development. Utilizing reversed phase chromatography on native protein and partially fragmented protein scientists can observe characteristics including heavy chain/light chain, Fc/Fab, or isoforms.

  • Peptide Mapping

    For protein characterization, peptide mapping is commonly used for identification of non-enzymatic, spontaneous post translational modifications, such as deamidation, oxidation, succinimide formation, pyroglutamate formation, and others. Reversed phase chromatography is used for confirming primary sequence, but is more commonly for PTM identification.

  • Peptide Quantitation

    The determination of signature peptide concentration from biological matrices using LC-MS. Scientists utilize peptide quantitation to deconvolute complex chromatograms by searching for specific peptide sequences, which can analyze the peptides with high sensitivity and specificity, even at low levels of peptide.

  • Charge Variant Analysis (IEX)

    Separate MABs from from acidic/basic variants .

  • Whether you are working with
  • novel proteins

    Complex large molecules composed of amino acid polymer chains. Proteins in biopharmaceuticals typically range from 3,000-150,000 kDa. Under the biologics classification, biopharmaceutical proteins can be hormones, human growth factors, and monoclonal antibodies (mAbs). The most common biopharmaceutical proteins are insulin and mAbs.

  • or biosimilars

    A biologic with the same sequence and similar function to an innovator biologic. The characterization of biosimilars requires the same chromatographic techniques as its corresponding innovator biologic

  • bioZen UHPLC columns are guaranteed
  • to help you achieve a new
  • state of Zen for your mind, body, soul, and lab.
 

Glycan Phase Detail


Glycan Phase Information


Phase: Sorbent Mass:
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Part Number:8M-S009-NGA

Description:BioZen N-Glycan Clean-Up, Microelution 96-Well Plate, 1/Pk

Sorbent Type:

Format:96-Well Plate

Phase:Mixed

Target Analytes:


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